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3368116 
Journal Article 
The effect of exhaust and non-exhaust related components of particulate matter on long-term survival after stroke in South London 
Desikan, A; Crichton, S; Hoang, U; Barratt, B; Kelly, FJ; Wolfe, C 
2015 
Yes 
International Journal of Stroke
ISSN: 1747-4930
EISSN: 1747-4949 
10 
61-62 
English 
WOS:000363731400149 
has other version or edition 3449541 Effect of exhaust- and nonexhaust-related components of particulate matter on long-term survival after stroke
is part of a larger document 3449542 Abstracts of the UK Stroke Forum 2015. Oral presentations, BASP breakfast session
Introduction: Outdoor air pollution represents a potentially modifiable risk factor for stroke. We examined the link between ambient pollution and mortality at 5 years post-stroke, especially for pollutants associated with vehicle exhaust.

Methods: Data from the South London Stroke Register, a population-based register covering an urban, multi-ethnic population was used. Hazard ratios (HR) for a one interquartile range increase in particulate matter <2.5 μm diameter (PM2.5) and <10 μm (PM10), were estimated post-stroke using Cox regression, overall and broken down into exhaust and non-exhaust components. Analysis was stratified by ischaemic subtypes (TACI, PACI, POCI, and LACI).

Results: The hazard of death following ischaemic stroke associated with PM2.5 up to 5 years after stroke was significantly elevated with HR = 1.05 (95%CI 1.009–1.092, p = 0.015) and borderline significant for PM10 (HR = 1.06 95%CI 0.998–1.12, p = 0.060). Within ischaemic subtypes, PM2.5 pollution increased mortality for TACI with a HR of 1.16 (95%CI 1.041–1.292, p = 0.007) but was not significant for any other subtype. Separating PM2.5 and PM10 into exhaust and non-exhaust components did not show increased mortality.

Conclusion: Exposure to certain outdoor particulate matter pollution, particularly particulate matter <2.5 μm diameter (PM2.5), increased morality risk post-stroke up to 5 years after the initial ischaemic stroke. 
NAAQS
• ISA-PM (2019)