US EPA

3696655 

Journal Article 

Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit 

Noreen, S; Shaheen, G; Akram, M; Rashid, A; Shah, S 

2016 

1 

Pakistan Journal of Pharmaceutical Sciences
ISSN: 1011-601X 

29 

4 

1383-1385 

English 

27592488 

WOS:000382352200009 

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0 +/- 1.15 activity but the activity was less than ascorbic acid i.e. 93.74 +/- 0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00 +/- 0.2a) with IC50 (392.66 +/- 2.1) followed by aqueous fraction (68.00 +/- 0.5e) with IC50 (159.83 +/- 2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities. 

Vaccinium macrocarpon; antiurease activity; anti-oxidant activity