Health & Environmental Research Online (HERO)


Print Feedback Export to File
3699525 
Journal Article 
Spectrophotometric Determination of Clonidine Hydrochloride through the Formation of Ion-Pair Complex 
Guimaraes, SS; Sousa, GD; Grangeiro Junior, S; Castelo Branco, DM; Albuquerque, MM; Leal, LB; Santana, DP 
2012 
0 
Latin American Journal of Pharmacy
ISSN: 0326-2383 
31 
8 
1222-1225 
WOS:000208861000018 
A simple, sensitive and accurate spectrophotometric method was developed for the determination of clonidine hydrochloride either in pure form or in pharmaceutical formulations. The developed method involves formation of colored chloroform extractable ion-pair complex of the clonidine hydrochloride with bromocresol green. The optimum conditions of the reactions were studied and optimized. The absorbance of yellow products was measured at 412 nm. Linearity ranges were found to be 1.25-12.5 mu g/mL. The method has the advantage of being highly sensitive and simple for determination of small dose drug and was applied to the determination of clonidine in capsules obtained in pharmaceutical compound. 
Clonidine hydrochloride; Ion-pair complex; Spectrophotometry 
• Chloroform 2018 Update
     TITLE AND ABSTRACT REVIEW
          Excluded Studies
• Chloroform Combined (current)
     Chloroform (original)
          References: 2000-2018
               WoS
     Chloroform (2018 update)
          TITLE AND ABSTRACT REVIEW
               Excluded Studies
     Chloroform (current)
          Literature Search: Jan 2009 - March 2017
               Web of Science