Low-temperature 1H-NMR spectroscopic study of doxorubicin influence on the hydrated properties of nanosilica modified by DNA | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3719271

Reference Type

Journal Article

Title

Low-temperature 1H-NMR spectroscopic study of doxorubicin influence on the hydrated properties of nanosilica modified by DNA

Author(s)

Turov, VV; Chehun, VF; Barvinchenko, VN; Krupskaya, TV; Prylutskyy, YI; Scharff, P; Ritter, U

Year

2011

Is Peer Reviewed?

Yes

Journal

Journal of Materials Science: Materials in Medicine
ISSN: 0957-4530
EISSN: 1573-4838

Volume

Issue

Page Numbers

525-532

Language

English

PMID

21287246

DOI

10.1007/s10856-011-4237-3

Abstract

The effect of the anticancer drug--doxorubicin (Dox) on hydration properties of a nanocomposite material deposited on silica and modified by small amount of DNA (0.6 wt%) was studied by means of (1)H NMR spectroscopy at low temperatures (in the range of 200-280 K). Signals of either weakly (WAW) or strongly (SAW) associated water, as well as water associated with electrondonor groups of the composite surface (ASW), were observed. The findings reveal that, depending on the temperature and the composition of the dispersion medium, fast molecular exchange takes place between different forms of interphase water. The presence of Dox (0.1-0.2 wt%) in the dispersion medium leads to change of the relative concentrations of different forms of water.