US EPA

3788876 

Journal Article 

Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women 

Llop, S; Lopez-Espinosa, MJ; Murcia, M; Alvarez-Pedrerol, M; Vioque, J; Aguinagalde, X; Julvez, J; Aurrekoetxea, JJ; Espada, M; Santa-Marina, L; Rebagliato, M; Ballester, F 

2015 

Yes 

Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 

138 

298-305 

English 

25749125 

10.1016/j.envres.2015.02.026 

WOS:000353011300033 

http://www.sciencedirect.com/science/article/pii/S0013935115000602
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AbstractObjective luate the association between mercury exposure and thyroid-stimulating hormone (TSH), total triiodothyronine (TT3) and free thyroxine (FT4) levels during pregnancy as well as to explore if there is any synergic action between mercury and intake of iodine from different sources. s udy population was 1407 pregnant women participating in the Spanish INMA birth cohort study. Total mercury concentrations were analyzed in cord blood. Thyroid hormones (THs) were measured in serum samples collected at 13.2±1.5 weeks of gestation. The association between mercury and TH levels was evaluated with multivariate linear regression models. Effect modification caused by iodine intake from supplements and diet was also evaluated. s ometric means of TSH, TT3, FT4 and mercury were 1.1 μU/L, 2.4 nmol/L, 10.5 pmol/L and 7.7 μg/L, respectively. Mercury levels were marginally significantly associated with TT3 (β: −0.05; 95%CI: −0.10, 0.01), but were neither associated with TSH nor FT4. The inverse association between mercury and TT3 levels was stronger among the iodine supplement consumers (−0.08; 95%CI: −0.15, −0.02, interaction p-value=0.07). The association with FT4 followed the same pattern, albeit not significant. sion al mercury exposure was inversely associated with TT3 levels among women who took iodine supplements during pregnancy. These results could be of public health concern, although further research is needed. 

Prenatal exposure; Endocrine disruption; Mercury; Thyroid; Iodine supplementation