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Citation
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HERO ID
3749285
Reference Type
Journal Article
Title
Inhalation toxicity of ammonium perfluorooctanoate
Author(s)
Kennedy, , Jr; Hall, GT; Brittelli, MR; Barnes, , JR; Chen, HC
Year
1986
Is Peer Reviewed?
Yes
Journal
Food and Chemical Toxicology
ISSN:
0278-6915
EISSN:
1873-6351
Report Number
NIOSH/00166513
Volume
24
Issue
12
Page Numbers
1325-1329
Language
English
PMID
3804135
DOI
10.1016/0278-6915(86)90066-9
Web of Science Id
WOS:A1986F722800011
Abstract
Ammonium perfluorooctanoate (CAS Registry No. 3825-26-1) is a fine white powder which can become airborne; hence its inhalation toxicity was studied in the male rat. The compound was found to be moderately toxic following single 4-hr exposures, with an LC50 of 980 mg/m3. This concentration produced both an increase in liver size and corneal opacity. Both findings diminished with increasing time after exposure. Subchronic head-only inhalation exposures (6 hr/day on 5 days/wk for 2 wk to 0, 1, 8 or 84 mg/m3) suppressed body-weight gain at 84 mg/m3. Reversible liver-weight increases, reversible increases in serum enzyme activities, and microscopic liver pathology, including necrosis, occurred at exposure of 8 and 84 mg/m3. No ocular changes were produced. Concentrations of organofluoride in the blood showed a dose relationship with initial levels of 108 ppm in rats treated at 84 mg/m3 falling to 0.84 ppm after 84 days with a blood half-life of 5-7 days. The no-observed-effect level was 1 mg/m3 and a mean organofluoride blood level of 13 ppm was detected in rats immediately after the tenth exposure to an atmospheric level of 1 mg ammonium perfluorooctanoate/m3.
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PFAS
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Additional PFAS (formerly XAgency)
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ATSDR
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Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
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Potassium perfluorooctanoate
Sodium perfluorooctanoate
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PFAS 150
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Ammonium perfluorooctanoate
Perfluorooctanoic acid
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R5-MI STSC Request
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Yale PFAS Liver study
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