US EPA

3987435 

Book/Book Chapter 

Male reproductive system 

Haschek, WM; Rousseaux, CG; Wallig, MA 

2009 

Yes 

Academic Press 

Cambridge, MA 

Fundamentals of toxicologic pathology 

553-597 

English 

10.1016/B978-0-12-370469-6.00018-0 

is a chapter of 3987436 Fundamentals of toxicologic pathology

The male reproductive system provides a multitude of potential sites for toxicologic disturbance. Effects on the developing reproductive system must be considered as well as effects on the functional adult system. The two systems are very different in their regulatory control and in their chemical sensitivity. A thorough knowledge of the structure and physiology of the system, as well as the kinetics and organization of spermatogenesis, is essential to understand toxicologic disturbances. Different mechanisms of toxicity generally result in different patterns of histo-pathologic change, but these are often only apparent during the early stages of lesion development. Elucidation of the critical molecular mechanisms underlying target cell toxicity in the reproductive system is extremely difficult. Despite extensive in vivo and in vitro investigations, the molecular mechanisms of most toxicants remain elusive. This is not only partly due to the complexity of intercellular communications and regulation but also due to an incomplete understanding of the basic reproductive physiology. However, appropriately designed investigations can yield important information on the target cell of toxicity, the reversibility of the lesion, the functional consequences of the injury, and the metabolic and pharmacokinetic profile of the toxicity. 

2nd 

9780123704696