Letter from Hooker Chem & Plastics Corp submitting information on the actions that have been taken to notify people who may be in contact with benzoyltrichloride & other materials | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4017186

Reference Type

Technical Report

Subtype

TSCA Submission

Title

Letter from Hooker Chem & Plastics Corp submitting information on the actions that have been taken to notify people who may be in contact with benzoyltrichloride & other materials

Author(s)

Hooker Chemical Company :: Hooker Chemical Co

Year

1981

Publisher

Submitted to the U.S. Environmental Protection Agency

Report Number

TSCATS/408801, OTS0204867, Doc #86-8000172, 8EHQ-0281-0360

Language

English

Relationship(s)

is part of a larger document 4017190 TSCA section 8(e) submission of information on the possible carcinogenicity of benzotrichloride, p-chlorobenzotrichloride and beyzoyl chloride

Abstract

4-Chlorobenzotrichloride was evaluated for toxicity in acute tests. Summary reports are presented. Acute oral tests in rats identified an LD50 value (and 95% confidence limits) of 820 (730 to 910) mg/kg. Decreased motor activity, tremors, diarrhea, piloerection, chromodaacryorrhea, and irritation to the gastrointestinal tract were noted. The acute dermal toxicity in rabbits was >2 g/kg. Skin reactions were mild to moderate, but persistent; no other toxic signs were noted. Primary skin irritation tests in rabbits indicated the substance is not corrosive, but causes erythema and edema. Eye irritation tests in rabbits showed no effect on the cornea and iris of rinsed or unrinsed eyes, but irritation to conjunctival tissue was observed in both groups. Preliminary results suggest the half-life of this material in pure water at 25 degrees Celsius is about 2.5 minutes.

NTIS Number

OTS0204867

TSCATS Number

TSCATS/408801