TSCATS/013364, OTS0204867, Doc #88-8000360, 8EHQ-0980-0360
Benzotrichloride, benzoyl chloride and 4- chlorobenzotrichloride were evaluated for chronic toxicity/carcinogenicity. Four Japanese reports and their English translations are presented. Female mice (8 to 12/group) were exposed to 1.6 ppm benzotrichloride 2x/week for 30 minutes over a 12 month period at room temperature or at 50 degrees Celsius, followed by an observation period of 12 or 15 months. Significant mortality resulted. Room temperature exposure caused pulmonary tumors (adenoma and adenocarcinoma). In all exposure groups, severe chronic bronchitis and bronchial pneumonia, skin papilloma and epidermoid carcinoma, keratinization of the gastric mucosa and hypertrophy of lymph nodes, liver, spleen, and kidney were seen. Similar exposure to benzoyl chloride for 5 months led to tumorous pulmonary lesions in 3/7 animals, 2 with adenocarcinoma. Inhalation exposure of mice to 6.8 ppm benzotrichloride for 5 months led to epithelial proliferation of the trachea and bronchi, pulmonary adenomas with malignant changes in some, and squamous cell carcinoma of the skin. Female mice were orally exposed to 0.0315 uL of benzotrichloride by stomach tube 2x/week for 25 weeks. A high incidence of cancer of the stomach, and development of tumors in the sweat gland, salivary gland, and hepatic vascular endothelium were noted. Similar exposure to 0.05 uL of p- chlorobenzotrichloride for 17.5 weeks led to stomach cancer, lymphatic tumors, and lung cancer. The carcinogenicity of benzotrichloride and p-chlorobenzotrichloride appeared to be similar. 4-Chlorobenzotrichloride was evaluated for toxicity in acute tests. Summary reports are presented. Acute oral tests in rats identified an LD50 value (and 95% confidence limits) of 820 (730 to 910) mg/kg. Decreased motor activity, tremors, diarrhea, piloerection, chromodaacryorrhea, and irritation to the gastrointestinal tract were noted. The acute dermal toxicity in rabbits was >2 g/kg. Skin reactions were mild to moderate, but persistent; no other toxic signs were noted. Primary skin irritation tests in rabbits indicated the substance is not corrosive, but causes erythema and edema. Eye irritation tests in rabbits showed no effect on the cornea and iris of rinsed or unrinsed eyes, but irritation to conjunctival tissue was observed in both groups. Preliminary results suggest the half-life of this material in pure water at 25 degrees Celsius is about 2.5 minutes. EPA Document Control No. 8ehq-0980-0360 Submission on Substantial Risk Notice. Information on the Possible Carcinogenicity of Benzotrichloride. Letter from Hooker Chem & Plastics Corp to USEPA Regarding Information on the Possible Carcinogenicity of Benzotrichloride, P-chlorobenzotrichloride & Benzoyl Chloride W-attachment. USEPA Status Report: Benzoyl Chloride, Benzotrichloride and P-chlorobenzotrichloride with Cover Letter dated 121580. Letter from Hooker Chem & Plastics Corp Submitting Information on the Actions That Have Been Taken to Notify People Who May be in Contact with Benzoyltrichloride & Other Materials. Letter from Hooker Chemicals & Plastics Corp to USEPA Submitting Information on the Possible Carcinogenicity of Benzo Trichloride with Attachments.