US EPA

4142829 

Journal Article 

Lanthanide Fluorobenzoates as Bio-Probes: a Quest for the Optimal Ligand Fluorination Degree 

Kalyakina, AS; Utochnikova, VV; Bushmarinov, IS; Le-Deygen, IM; Volz, D; Weis, P; Schepers, U; Kuzmina, NP; Bräse, S 

2017 

Yes 

Chemistry: A European Journal
ISSN: 0947-6539
EISSN: 1521-3765 

23 

59 

14944-14953 

English 

28833886 

10.1002/chem.201703543 

WOS:000413337400033 

The thorough study of fluorinated benzoates of lanthanides (Eu, Tb, Nd, Er, Yb, Gd, La, Lu) is reported. Their composition in single crystal and powder state revealed two predominant structural motifs. An in-depth luminescence study has been performed on the reported fluorobenzoates, showing, that terbium and europium complexes in solid state possess high luminescence intensity with the quantum yield of up to 69 %. High solubility in most organic solvents, as well as in water, combined with the high luminescence intensity in water solution and non-toxicity allowed the testing of europium complexes as bioprobes in cellulo. Among all tested fluorobenzoates, europium 2-fluorobenzoate dihydrate combined the best luminescent properties, thermodynamic stability, aqueous solubility, and non-toxicity, and was shown to be a viable bio-marker.