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Citation
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HERO ID
4165772
Reference Type
Journal Article
Title
Inhalation of fine particulate matter impairs endothelial progenitor cell function via pulmonary oxidative stress
Author(s)
Haberzettl, P; Conklin, DJ; Abplanalp, WT; Bhatnagar, A; O'Toole, TE
Year
2018
Is Peer Reviewed?
1
Journal
Arteriosclerosis, Thrombosis, and Vascular Biology
ISSN:
1079-5642
EISSN:
1524-4636
Volume
38
Issue
1
Page Numbers
131-142
Language
English
PMID
29191925
DOI
10.1161/ATVBAHA.117.309971
Web of Science Id
WOS:000418861700019
Abstract
OBJECTIVE:
Exposure to fine particulate matter (PM2.5) air pollution is associated with the depletion of circulating endothelial progenitor cells (EPCs), as well as vascular injury and dysfunction. Nevertheless, it remains unclear whether PM2.5 exposure leads to significant impairments in EPC function. Hence, we studied the effects of PM2.5 on EPC-mediated recovery of vascular perfusion after hindlimb ischemia and examined the mechanisms whereby PM2.5 exposure affects EPC abundance and function.
APPROACH AND RESULTS:
In comparison with EPCs isolated from mice breathing filtered air, EPCs from mice exposed for 9 consecutive days (6 hours per day) to concentrated ambient PM2.5 (CAP) had defects in both proliferation and tube formation. However, CAP exposure of mice overexpressing extracellular superoxide dismutase (ecSOD-Tg) in the lungs did not affect EPC tube formation. Exposure to CAP also suppressed circulating EPC levels, VEGF (vascular endothelial growth factor)-stimulated aortic Akt phosphorylation, and plasma NO levels in wild-type but not in ecSOD-Tg mice. EPCs from CAP-exposed wild-type mice failed to augment basal recovery of hindlimb perfusion when injected into unexposed mice subjected to hindlimb ischemia; however, these deficits in recovery of hindlimb perfusion were absent when using EPCs derived from CAP-exposed ecSOD-Tg mice. The improved reparative function of EPCs from CAP-exposed ecSOD-Tg mice was also reflected by greater expression of Mmp-9 and Nos3 when compared with EPCs from CAP-exposed wild-type mice.
CONCLUSIONS:
Exposure to PM2.5 impairs EPC abundance and function and prevents EPC-mediated vascular recovery after hindlimb ischemia. This defect is attributed, in part, to pulmonary oxidative stress and was associated with vascular VEGF resistance and a decrement in NO bioavailability.
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NAAQS
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ISA-PM (2019)
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LitSearch-NOx (2024)
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Exposure
Confounding
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PIA
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Toxicology
Nitric Oxide
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