US EPA

4192025 

Journal Article 

Electrochemical synthesis of 2-amino-5-substituted-1,3,4-oxadiazole derivatives and evaluation of antibacterial activity 

Kumar, S; Pandey, HN 

2013 

1 

Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 

NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR 

NEW DELHI 

52 

2 

252-258 

English 

WOS:000315133300002 

Some new 2-amino-5-substituted-1,3,4-oxadiazoles have been synthesized at platinum electrode through theelectrochemical oxidation of semicarbazone at room temperature and studied for their antibacterial activity. This is an environmentally benign method in the field of electroorganic synthesis under controlled potential electrolysis in an undivided cell. The electrolysis have been carried out in the acetonitrile solvent and lithium perchlorate is used as a supporting electrolyte. Two platinum plates are used as working as well as counter electrode and saturated calomel electrode as the reference electrode. These compounds have been characterized by microanalyses, IR, Mass, H-1 NMR and C-13 NMR spectral data. All the compounds have been evaluated for their antibacterial activity against Klebsilla penumoniae, Escherichia coli, Streptococcus aureus and Shigella dysenteriea at 25 and 50 ppm concentrations. 

2-Amino-1,3,4-oxadiazoles; electrooxidation; electrolysis; antibacterial activity