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4353919 
Technical Report 
EPA Report 
DuPont-24113: FRD-902: Acute dermal toxicity study in rats 
Carpenter, C 
2007 
E.I. du Pont de Nemours and Company 
Newark, Delaware 
29 
English 
A single dose of FRD-902 was applied to the shaved, intact skin of 5 male and 5 female rats at a dose of 5000 mg/kg of body weight. The application site was covered with a semi-occlusive dressing for 24 hours, after which the test substance was removed. The rats were observed for 14 days following application. The rats were necropsied to detect grossly observable evidence of organ or tissue damage at the end of the 15-day test period.

No deaths occurred. The rats exhibited no clinical signs of systemic toxicity or body weight loss. No erythema or edema was observed on the test site of male rats. All female rats exhibited erythema (score of 2) but no edema on the test site the day after application of the test substance. No erythema was observed in these rats by 2 days after application. Hyperkeratosis was observed on the test site of 8 rats, and ulceration was observed on the test site of 3 rats during the study. All dermal effects cleared by 13 days after application. No gross lesions were present in the rats at necropsy.

Under the conditions of this study, the skin absorption LD50 for FRD-902 was greater than 5000 mg/kg of body weight when applied to the skin of male and female rats for 24 hours.

In accordance with the provisions of Directive 67/548/EEC, classification by the dermal route is not required based on the results of this study