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HERO ID
4244887
Reference Type
Journal Article
Title
GABAergic transmission during brain development: Multiple effects at multiple stages
Author(s)
Kirmse, K; Hübner, CA; Isbrandt, D; Witte, OW; Holthoff, K
Year
2018
Is Peer Reviewed?
1
Journal
Neuroscientist
ISSN:
1073-8584
EISSN:
1089-4098
Volume
24
Issue
1
Page Numbers
36-53
Language
English
PMID
28378628
DOI
10.1177/1073858417701382
Web of Science Id
WOS:000419145900007
Abstract
In recent years, considerable progress has been achieved in deciphering the cellular and network functions of GABAergic transmission in the intact developing brain. First, in vivo studies in non-mammalian and mammalian species confirmed the long-held assumption that GABA acts as a mainly depolarizing neurotransmitter at early developmental stages. At the same time, GABAergic transmission was shown to spatiotemporally constrain spontaneous cortical activity, whereas firm evidence for GABAergic excitation in vivo is currently missing. Second, there is a growing body of evidence indicating that depolarizing GABA may contribute to the activity-dependent refinement of neural circuits. Third, alterations in GABA actions have been causally linked to developmental brain disorders and identified as potential targets of timed prophylactic interventions. In this article, we review these major recent findings and argue that both depolarizing and inhibitory GABA actions may be crucial for physiological brain maturation.
Keywords
GABA; brain development; in vivo; inhibition; epilepsy
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IRIS
•
RDX (121-82-4)
SAB 2017 references
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