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4249555 
Journal Article 
Mastering ozonolysis: production from laboratory to ton scale in continuous flow 
Nobis, M; Roberge, DM 
2011 
Yes 
Chimica Oggi
ISSN: 0392-839X 
29 
1 
56-58 
WOS:000287464100014 
In most cases, ozonolysis is more sustainable and cost effective for the oxidative treatment of organic unsaturated compounds than other oxidation technologies. To enable the scalability of this challenging gas-liquid oxidation process, Lonza has developed a novel approach that combines microreactors, a bench-scale reactor, and a large scale production reactor. The approach also includes laboratory feasibility studies and technical transfer - with hazard evaluations and safety assessments - to successful large scale manufacturing. 
Ozone; Ozonolysis; Oxidation; Scale-up; Microreactor Technology; Microreactors; Continuous Flow Processes; Green Chemistry; Sustainability