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HERO ID
4250425
Reference Type
Journal Article
Title
Fluoroform as a feedstock for high-value fluorochemicals: novel trends and recent developments
Author(s)
Grushin, VV
Year
2014
Is Peer Reviewed?
Yes
Journal
Chimica Oggi
ISSN:
0392-839X
Volume
32
Issue
3
Page Numbers
81-88
Web of Science Id
WOS:000339906500015
Abstract
Trifluoromethylated building blocks and intermediates are in exceptionally high demand for the synthesis of agrochemicals, pharmaceuticals, and specialty materials. Readily available, nontoxic and ozone-friendly fluoroform (CHF3, trifluoromethane, HFC-23), a side-product of Teflon manufacturing and a potent greenhouse gas, would be by far the best CF3 source for a variety of trifluoromethylation reactions. Chemoselective activation of fluoroform, however, is highly challenging. This article provides an overview of synthetic methods employing fluoroform with emphasis on new trends and most recent, promising developments in the area.
Keywords
fluoroform; HFC-23; trifluoromethylation; transition metal reagents and catalysts; organofluorine compounds
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ISA-Ozone (2020 Final Project Page)
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PFAS
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PFAS Universe
Data Source
Web of Science
Trifluoromethane
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