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4262896 
Journal Article 
SYRCLE’s risk of bias tool for animal studies 
Hooijmans, CR; Rovers, MM; De Vries, RB; Leenaars, M; Ritskes-Hoitinga, M; Langendam, MW 
2014 
Yes 
BMC Medical Research Methodology
ISSN: 1471-2288 
14 
1 
43 
English 
24667063 
WOS:000334439900001 
Systematic Reviews (SRs) of experimental animal studies are not yet common practice, but awareness of the merits of conducting such SRs is steadily increasing. As animal intervention studies differ from randomized clinical trials (RCT) in many aspects, the methodology for SRs of clinical trials needs to be adapted and optimized for animal intervention studies. The Cochrane Collaboration developed a Risk of Bias (RoB) tool to establish consistency and avoid discrepancies in assessing the methodological quality of RCTs. A similar initiative is warranted in the field of animal experimentation. 
Risk of bias; Methodological quality; Animal studies; Systematic reviews; Tool; Translational research 
IRIS
• Chromium VI
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