US EPA

4272080 

Journal Article 

Review 

Inflammation, metaflammation and immunometabolic disorders 

Hotamisligil, GS 

2017 

1 

Nature
ISSN: 0028-0836
EISSN: 1476-4687 

542 

7640 

177-185 

English 

28179656 

10.1038/nature21363 

Proper regulation and management of energy, substrate diversity and quantity, as well as macromolecular synthesis and breakdown processes, are fundamental to cellular and organismal survival and are paramount to health. Cellular and multicellular organization are defended by the immune response, a robust and critical system through which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and tissue homeostasis is safeguarded. Many layers of evolutionarily conserved interactions occur between immune response and metabolism. Proper maintenance of this delicate balance is crucial for health and has important implications for many pathological states such as obesity, diabetes, and other chronic non-communicable diseases.