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4298441 
Journal Article 
Bromolactonization of alkenoic acids mediated by V2O5 via bromide to bromenium in situ oxidation 
Campbell, ML; Rackley, SA; Giambalvo, LN; Whitehead, DC 
2014 
1 
Tetrahedron Letters
ISSN: 0040-4039
EISSN: 1873-3581 
55 
41 
5680-5682 
WOS:000342882000024 
An efficient protocol for the bromolactonization of alkenoic acids is presented that obviates the use of molecular bromine or exogenous bromenium sources. Vanadium (V) oxide catalyzes the in situ oxidation of bromide salts to bromenium (Br+) in a process mediated by urea-hydrogen peroxide complex. Initial mechanistic investigations indicate that the presence of urea does not accelerate the halolactonization reaction. (C) 2014 Elsevier Ltd. All rights reserved. 
Bromolactonization; Halenium equivalent; Alkenoic acid; Vanadium oxide