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Applied concepts in PBPK modeling: How to extend an open systems pharmacology model to the special population of pregnant women
Dallmann, A; Solodenko, J; Ince, I; Eissing, T
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CPT: Pharmacometrics & Systems Pharmacology
This tutorial presents the workflow of adapting an adult physiologically based pharmacokinetic (PBPK) model to the pregnant populations using the Open Systems Pharmacology (OSP) software suite (www.open-systems-pharmacology.org). This workflow is illustrated using a previously published PBPK model for metronidazole that is extrapolated to pregnancy by parameterizing and extending the model structure in terms of pregnancy-induced physiological changes. Importantly, this workflow can be applied to other scenarios where PBPK models need to be re-parameterized or structurally modified.
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