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HERO ID
4470804
Reference Type
Journal Article
Title
Materno-fetal pharmacokinetics and fetal distribution of valproic acid in a pregnant rhesus monkey
Author(s)
Dickinson, RG; Lawyer, CH; Kaufman, SN; Lynn, RK; Gerber, N; Novy, MJ; Cook, MJ
Year
1980
Is Peer Reviewed?
0
Journal
Pediatric Pharmacology
ISSN:
0270-322X
Volume
1
Issue
1
Page Numbers
71-83
Language
English
PMID
6810290
Abstract
Chronic indwelling catheters in the maternal femoral artery and vein, fetal carotid artery and jugular vein, and amniotic cavity of a pregnant rhesus monkey permitted administration of sodium valproate (NaVPA) and collection of timed samples of maternal and fetal blood and amniotic fluid. After a single IV dose (50 mg/kg) to the mother, a rapid distribution phase (t1/2 alpha = 0.5 minute) was followed by a biphasic decline in concentration in maternal blood (t1/2 beta = 31 minutes, t1/2 gamma = 390 minutes). VPA appeared rapidly in fetal blood, reached a concentration slightly higher than in maternal blood by 15 minutes, and thereafter declined in parallel with the concentration in maternal blood. Terminal fetal/maternal ratios of blood concentration of VPA were about 1.3. Similar patterns of decline were observed after NaVPA was given IV to the fetus. A multicompartment first-order materno-fetal pharmacokinetic model is presented. Tissue distribution studies in the fetus showed that VPA concentration was highest in blood; moderate in heart, liver, spleen, kidney, and skeletal muscle; and low in brain.
Tags
NAAQS
•
ISA-PM (2019)
In Scope
Exposure
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