US EPA

4641604 

Journal Article 

Anti-obesity effect of Triticum aestivum sprout extract in high-fat-diet-induced obese mice 

Im, JY; Ki, HH; Xin, M; Kwon, SU; Kim, YH; Kim, DK; Hong, SP; Jin, JS; Lee, YM 

2015 

Yes 

Bioscience, Biotechnology, and Biochemistry
ISSN: 0916-8451
EISSN: 1347-6947 

79 

7 

1133-1140 

English 

25925980 

10.1080/09168451.2015.1006567 

WOS:000357330200017 

Obesity is a common disease worldwide that often results in serious conditions including hypertension, diabetes, and hyperlipidemia. Many herbal medicines have been examined with regard to ameliorating obesity. We investigated the anti-obesity effects of 50% EtOH extract of Triticum aestivum sprout (TAEE) in high-fat-diet (HFD)-induced obese mice. TAEE administration (10, 50, or 200 mg/kg) for 6 weeks significantly decreased the body weights, serum total cholesterol (TC), and low-density lipoprotein cholesterol levels in HFD-fed mice. TAEE treatment reduced lipid accumulation in epididymal white adipose tissue (EWAT) and liver. Moreover, TC and lipid levels were decreased by TAEE treatment in liver. Serum leptin and adiponectin concentrations were reduced by TAEE treatment. TAEE-treated mice showed decreases in peroxisome proliferator-activated receptor γ (PPARγ) and fatty acid synthase expression in EWAT. Furthermore, TAEE administration elevated levels of PPARα protein in the liver of HFD-induced obese mice. These results suggest that TAEE supplementation might be beneficial for the treatment and prevention of obesity and related diseases.