US EPA

4644402 

Journal Article 

Review 

Fibromyalgia and nutrition: Therapeutic possibilities? 

Bjørklund, G; Dadar, M; Chirumbolo, S; Aaseth, J 

2018 

Yes 

Biomedicine & Pharmacotherapy
ISSN: 0753-3322
EISSN: 1950-6007 

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER 

ISSY-LES-MOULINEAUX 

103 

531-538 

English 

29677539 

10.1016/j.biopha.2018.04.056 

WOS:000433328800065 

http://://BCI:BCI201800602144
Exit
 

Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vitamins B and D, as well as with the harmful effects of heavy metals, such as mercury, cadmium, and lead. Research indicates that patients deficient in certain essential nutrients may develop dysfunction of pain inhibitory mechanisms together with fatigue and other FM symptoms. Additionally, mercury and other toxic elements may interfere with the bioavailability of essential nutrients. This review examines the many effects of metals and vitamins in pain evaluation of FM patients. Dietary guidance is therefore critical for FM patients to help them in correcting a suboptimal or deficient intake of essential nutrients. When optimal levels of nutrition are achieved, pain levels are usually lowered. Additional research is recommended in the field of FM and nutrition to disclose further possible relationships.