Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
4650996
Reference Type
Journal Article
Title
Association of co-exposure to heavy metals with renal function in a hypertensive population
Author(s)
Wu, W; Zhang, K; Jiang, S; Liu, D; Zhou, H; Zhong, R; Zeng, Q; Cheng, L; Miao, X; Tong, Y; Lu, Q
Year
2018
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Volume
112
Page Numbers
198-206
Language
English
PMID
29275245
DOI
10.1016/j.envint.2017.12.023
Web of Science Id
WOS:000429420500021
Abstract
BACKGROUND: Chronic kidney disease (CKD) is an increasing health problem worldwide. Recent studies have suggested the potential associations between exposure to metals and CKD events, particularly in participants with hypertension. However, relevant studies are limited.
OBJECTIVES: We aimed to explore the associations of metal exposure with renal function in participants with essential hypertension.
METHODS: Nine hundred and thirty-four participants with essential hypertension were recruited at the Department of Cardiology, Union Hospital, Wuhan, China. We measured the levels of chromium, cadmium, thallium and uranium in urine and calculated the estimated glomerular filtration rate (eGFR) for renal function. Multivariable linear regression models adjusted for potential confounders were applied.
RESULTS: After adjusting for potential confounders and other metals, doubling of urinary chromium or uranium levels decreased eGFR by 2.90 (95% confidence interval, 2.04 to 3.76) and 1.87 (0.58 to 3.15) mL/min per 1.73m2, respectively. Co-exposure to chromium and uranium was found to greatly decrease eGFR, particularly in women. Compared with those in the low exposure group, women with high exposure to chromium and uranium had a 11.36 (3.66 to 19.07) mL/min per 1.73m2 adjusted decline in eGFR. Higher urinary thallium levels were positively related to elevated eGFR in men. The adjusted increase in eGFR with doubling of thallium levels was 3.12 (1.14 to 5.10) mL/min per 1.73m2. Sex-difference in the associations of exposure to heavy metals with eGFR was also suggested.
CONCLUSIONS: Our findings suggest that environmental exposure to chromium and uranium might contribute to a decline in eGFR in individuals with hypertension. The associations of exposure to heavy metals with eGFR might be sex-different. Further studies are warranted to confirm our findings and clarify the underlying mechanisms.
Keywords
Chromium; Cadmium; Thallium; Uranium; Renal function; Hypertension
Tags
•
Nitrate/Nitrite
LitSearch Update 2018/1/1 - 2022/8/17
WoS
•
Uranium
WOS
Uranium Literature Search Update 7/2018
WOS
Uranium Literature Search Update 4/2020
WOS
•
Uranium Toxicological Review
Screening
Included
Human Study
Date limited literature search 2011-2021
WOS
Scopus
New to this search
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity