US EPA

4654103 

Journal Article 

Effect of styrene maleic acid WIN55,212-2 micelles on neuropathic pain in a rat model 

Linsell, O; Brownjohn, PW; Nehoff, H; Greish, K; Ashton, JC 

2015 

Yes 

Journal of Drug Targeting
ISSN: 1061-186X 

INFORMA HEALTHCARE 

LONDON 

23 

4 

353-359 

English 

25541465 

10.3109/1061186X.2014.997737 

WOS:000352857100007 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927709968&doi=10.3109%2f1061186X.2014.997737&partnerID=40&md5=ade9ab6e6e059b786c045d2b970c6532
Exit
 

Cannabinoid receptor agonists are moderately effective at reducing neuropathic pain but are limited by psychoactivity. We developed a styrene maleic acid (SMA) based on the cannabinoid WIN 55,212-2 (WIN) and tested in a rat model of neuropathic pain and in the rotarod test. We hypothesized that miceller preparation can ensure prolonged plasma half-life being above the renal threshold of excretion. Furthermore, SMA-WIN could potentially reduce the central nervous system effects of encapsulated WIN by limiting its transport across the blood-brain barrier. Using the chronic constriction injury model of sciatic neuropathy, the SMA-WIN micelles were efficacious in the treatment of neuropathic pain for a prolonged period compared to control (base WIN). Attenuation of chronic constriction injury-induced mechanical allodynia occurred for up to 8 h at a dose of 11.5 mg/kg of SMA-WIN micelles. To evaluate central effects on motor function, the rotarod assessment was utilized. Results showed initial impairment caused by SMA-WIN micelles to be identical to WIN control for up to 1.5 h. Despite this, the SMA-WIN micelle formulation was able to produce prolonged analgesia over a time when there was decreased impairment in the rotarod test compared with base WIN. 

212-2; Cannabinoid; Nanoparticle; Neuropathic pain; Rotarod; Styrene maleic acid