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4674236 
Journal Article 
Topical skin targeting effect of penetration modifiers on hairless mouse skin, pig abdominal skin and pig ear skin 
Yu, M; Guo, F; Ling, Y; Li, N; Tan, F 
2015 
Yes 
Drug Delivery
ISSN: 1071-7544 
22 
8 
1053-1058 
English 
24329579 
WOS:000366272600008 
OBJECTIVE: This study was to investigate the topical skin targeting effects and mechanism of combination penetration modifiers of 1,2-hexanediol (or 1,2-heptanediol) and 1,4-cyclohexanediol on transdermal absorption of metronidazole (MTZ) in different skin models.

METHODS: Six formulations were applied to pig abdominal skin and pig ear skin models, respectively, and the results were compared with the previous data on hairless mouse skin worked out by our laboratory. Four parameters (flux, Tlag, Q24 and targeting ratio) were used to evaluate permeability and targeting effect in skin.

RESULTS: The combined penetration modifiers played a general role on decreasing permeability without reducing skin retention. The most significant skin permeability decrement to MTZ was pig abdominal skin (permeability decrement was ∼20% for hairless mouse skin, 60% for pig abdominal skin and 40% for pig ear skin, respectively) while the strongest skin targeting effect appeared in hairless mouse skin (targeting ratios were 1.79 for hairless mouse skin, 1.24 for pig abdominal skin and 1.05 for pig ear skin, respectively) under the role of penetration modifiers.

CONCLUSIONS: Thickness of stratum corneum (SC) was the major factor impact on skin targeting effect. Selection criteria of skin models also have been discussed in this study. 
OPPT
• 1,2-Hexanediol
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