Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

4998

Reference Type

Journal Article

Title

Age-specific models of mortality and tumor onset for historical control animals in the National Toxicology Program's carcinogenicity experiments

Author(s)

Portier, CJ; Hedges, JC; Hoel, DG

Year

1986

Is Peer Reviewed?

Yes

Journal

Cancer Research
ISSN: 0008-5472
EISSN: 1538-7445

Publisher

AMER ASSOC CANCER RESEARCH

Location

PHILADELPHIA

Report Number

BIOSIS/86/34952

Volume

Issue

Page Numbers

4372-4378

Language

English

PMID

3731095

Web of Science Id

WOS:A1986D705300010

Abstract

This paper models general survival and the distribution of tumor onset times for various tumors in the data base of control animals developed by the National Toxicology Program. For general survival, a modified Weibull model is shown to give an adequate fit for both Fischer 344 rats and C57BL/6 x C3H F1 mice. In addition, data from control animals in a lifetime study of asbestos are used to support the extension of these survival curves beyond 2 years in Fischer rats. The distributions of tumor onset times are modeled using a two-parameter Weibull model. For many common tumor types, this model yielded a very good fit to the data. Finally, a summary measure of the contribution of a tumor to mortality is given.

Keywords

Carcinogens; Index Medicus; Models, Theoretical; Animals; Age Factors; Disease Models, Animal; Neoplasms, Experimental -- mortality

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