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Citation
Tags
HERO ID
5018061
Reference Type
Journal Article
Title
The Comparison of Surface Free Energy of Human, Yucatan Micropig, and Hairless Mouse Skins and Influence of Surfactant on Surface Free Energy of the Skin
Author(s)
Fujii, M; Kato, K; Imai, M; Kuwabara, H; Awano, M; Hashizaki, K; Taguchi, H
Year
2019
Is Peer Reviewed?
Yes
Journal
Biological and Pharmaceutical Bulletin
ISSN:
0918-6158
EISSN:
1347-5215
Volume
42
Issue
2
Page Numbers
295-298
Language
English
PMID
30504641
DOI
10.1248/bpb.b18-00749
Web of Science Id
WOS:000457511800019
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061037308&doi=10.1248%2fbpb.b18-00749&partnerID=40&md5=3803122edec822a15a4b9378c8eabd92
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Abstract
Surface free energy (SFE) is an important factor for evaluation of wettability or adhesion. Thus, the SFE of a Yucatan micropig (YMP) skin and a hairless mouse (HM) skin, which are commonly used in skin permeation studies instead of human skin, were compared with the human skin. Contact angles of water and 1-bromo naphthalene to skin were measured and the SFE was calculated using the Owens-Wendt equation. The SFE of the human abdominal skin was 40 mN/m and its polar component σsp was as low as 2 mN/m, which was similar to that of the low sebum skin reported previously. In the case of the YMP skin, σsp was high on the surface but similar to that obtained after the skin was tape-stripped twice. The HM skin showed similar SFE as that of the human skin. When the surfactant was applied on the skin, wiped, and dried, the remaining surfactant increased the SFE in σsp; however, the original SFE was obtained after rinsing with water. The YMP skin and HM skin is similar to the human abdominal skin with a low sebum level. Thus, they are also good skin models for studying wettability or adhesion of a substance.
Tags
IRIS
•
Naphthalene
Database Searches
PubMed
WOS
Combined data set
Data set for title/abstract screening
Excluded - PECO criteria not met (TIAB)
Feb 2019 Update
PubMed
January 2021 Update
WOS
Other
•
Naphthalene (2021 Evidence mapping publication)
Database Searches
PubMed
WOS
Combined data set
Data set for title/abstract screening
Excluded – PECO criteria not met
Feb 2019 Update
PubMed
January 2021 Update
WOS
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