A ratiometric fluorescent probe for hydrazine detection with large fluorescence change ratio and its application for fluorescence imaging in living cells | Health & Environmental Research Online (HERO)

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HERO ID

5018339

Reference Type

Journal Article

Title

A ratiometric fluorescent probe for hydrazine detection with large fluorescence change ratio and its application for fluorescence imaging in living cells

Author(s)

Liu, C; Liu, K; Tian, M; Lin, W

Year

2018

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Journal

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
ISSN: 1386-1425
EISSN: 1873-3557

Volume

212

Page Numbers

42-47

Language

English

PMID

30594852

DOI

10.1016/j.saa.2018.12.026

Web of Science Id

WOS:000471307100006

URL

http://://WOS:000471307100006
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Abstract

Hydrazine and its derivatives are one of the most important raw chemical materials that have extensive utilization in many areas. It is also widely applied as pharmaceutical derivatives, such as the antipsychotic drug, anti-infective drug, and antitumor drug. However, hydrazine is a highly toxic reagent which can bring severe damage to human and animals. Herein, we have reported a new benzothiazole substituted naphthalene based probe for hydrazine with huge fluorescence change ratio. The fluorescence change ratio at F390/F509 is up to 200-fold in the presence of hydrazine in 60 min. The probe exhibited negligible cytotoxicity toward HeLa cells and was applied for hydrazine detection successfully in HeLa cells.

Keywords

Fluorescent probe; Hydrazine detection; Ratiometric; Cell imaging

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