Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

5020753

Reference Type

Journal Article

Title

Epigenetic meta-analysis across three civilian cohorts identifies NRG1 and HGS as blood-based biomarkers for post-traumatic stress disorder

Author(s)

Uddin, M; Ratanatharathorn, A; Armstrong, D; Kuan, PF; Aiello, AE; Bromet, EJ; Galea, S; Koenen, KC; Luft, B; Ressler, KJ; Wildman, DE; Nievergelt, CM; Smith, A

Year

2018

Is Peer Reviewed?

Yes

Journal

Epigenomics
ISSN: 1750-1911

Language

English

PMID

30456986

DOI

10.2217/epi-2018-0049

Web of Science Id

WOS:000452668200006

Abstract

AIM: Trauma exposure is a necessary, but not deterministic, contributor to post-traumatic stress disorder (PTSD). Epigenetic factors may distinguish between trauma-exposed individuals with versus without PTSD.

MATERIALS & METHODS: We conducted a meta-analysis of PTSD epigenome-wide association studies in trauma-exposed cohorts drawn from civilian contexts. Whole blood-derived DNA methylation levels were analyzed in 545 study participants, drawn from the three civilian cohorts participating in the PTSD working group of the Psychiatric Genomics Consortium.

RESULTS: Two CpG sites significantly associated with current PTSD in NRG1 (cg23637605) and in HGS (cg19577098).

CONCLUSION: PTSD is associated with differential methylation, measured in blood, within HGS and NRG1 across three civilian cohorts.