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5043570 
Journal Article 
Graphene nanoplatelets in potentiometry: A nanocomposite carbon paste and PVC based membrane sensors for analysis of Vilazodone HCl in plasma and milk samples 
El-Kosasy, AM; Abdel Rahman, MH; Abdelaal, SH 
2019 
1 
Talanta
ISSN: 0039-9140
EISSN: 1873-3573 
193 
9-14 
English 
30368303 
Graphene is the ''new star'' material for electrochemical sensing. It has unique mechanical, thermal and electrical properties, in addition to its ultra light weight. In the present work we combine for the first time the special features offered by graphene and the advantages of ion selective potentiometric sensors in a single study. We propose two types of sensors, a graphene based carbon paste and a poly vinyl chloride (PVC) based membrane sensors for the analysis of Vilazodone hydrochloride in bulk, human plasma and formula milk samples. Electro active agent is an ion- association complex based on coupling of Vilazodone cationic cite with anionic cite of Molybdate ion in a ratio 1:1. Both sensors are evaluated according to the IUPAC recommendation data, revealing linear response in the concentration range 10-7 - 10-3 and10-8 - 10-3 M with a Nernestian slope 59.89 and 59.91 mV/decade for PVC membrane and Carbon paste sensors, respectively. Both sensors were successfully applied to the analysis of Vilazodone HCl in human plasma and formula milk samples showing good recovery percentage values. Graphene based carbon paste sensor shows several advantages over conventional PVC membrane sensor regarding lower limit of detection, faster response time, longer life time and higher selectivity towards target ion. 
Antidepressive Agents/blood; Diethylhexyl Phthalate/chemistry; Graphite/chemistry; Hydrogen-Ion Concentration; Infant Formula/analysis; Infant, Newborn; Limit of Detection; Molybdenum/chemistry; Nanocomposites/chemistry; Polyvinyl Chloride/chemistry; Potentiometry/instrumentation/methods; Vilazodone Hydrochloride/blood; Bio analysis; Graphene nanoplatelets; Ion selective electrodes; Poly vinyl chloride; Vilazodone HCl; 7782-42-5; 81AH48963U; 9002-86-2; C42K0PH13C; OGI154X474; U8HTX2GK8J