Journal Article
Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying
Ogienko, AG; Stoporev, AS; Ogienko, AA; Mel'gunov, MS; Adamova, TP; Yunoshev, AS; Manakov, AY; Boldyreva, EV
Chemical Communications
ISSN: 1359-7345
EISSN: 1364-548X
The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).
