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Citation
Tags
HERO ID
5343825
Reference Type
Journal Article
Title
Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying
Author(s)
Ogienko, AG; Stoporev, AS; Ogienko, AA; Mel'gunov, MS; Adamova, TP; Yunoshev, AS; Manakov, AY; Boldyreva, EV
Year
2019
Is Peer Reviewed?
Yes
Journal
Chemical Communications
ISSN:
1359-7345
EISSN:
1364-548X
Volume
55
Issue
29
Page Numbers
4262-4265
Language
English
PMID
30906942
DOI
10.1039/c9cc00397e
Abstract
The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).
Tags
IRIS
•
tert-Butanol
Excluded/ Not on Topic
Methodology/Solvent
LitSearch: Jan 2017 - July 2019
PubMed
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