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Citation
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HERO ID
56332
Reference Type
Journal Article
Subtype
Review
Title
Genetic polymorphisms of alcohol metabolizing enzymes
Author(s)
Agarwal, DP
Year
2001
Is Peer Reviewed?
1
Journal
Pathologie et Biologie
ISSN:
0369-8114
Volume
49
Issue
9
Page Numbers
703-709
Language
English
PMID
11762132
DOI
10.1016/S0369-8114(01)00242-5
Web of Science Id
WOS:000172360900006
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035188749&doi=10.1016%2fS0369-8114%2801%2900242-5&partnerID=40&md5=d293ea6d473f4c2c10623d287ec9c16a
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Abstract
Alcohol metabolism is one of the biological determinants that can significantly influence drinking behavior and the development of alcoholism and alcohol-induced organ damage. Most ethanol elimination occurs by oxidation to acetaldehyde and acetate, catalyzed principally by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Other ethanol oxidation pathways, including catalase and microsomal ethanol-oxidizing system (MEOS/CYP2E1), as well as the nonoxidative pathway (FAEES), which forms fatty acid ethyl esters, appear to play a minor role. The major alcohol metabolizing enzymes exhibit genetic polymorphism and ethnic variation. In this review recent advances in the understanding of the functional polymorphisms of ADH, ALDH and CYP2E1 and their metabolic, physiologic and clinical correlations are presented.
Keywords
ADH; alcohol metabolism; ALDH; CYP2E1; genetic polymorphism
Tags
•
Methanol (Non-Cancer)
Cited in Final (2013)
Cited in External Review Draft (2013)
Cited in External Review Draft (2011)
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