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574815 
Journal Article 
Evaluation of neurotoxic effects of lead acetat on rat radial nerve; 0312 in: Abstracts of the XVIIIth World Congress of Neurology, 5-11 November 2005, Sydney, Australia 
Mehdizadeh, M; Kermanian, F; Farjah, G; Tabatabaei, PN 
2005 
Yes 
Journal of the Neurological Sciences
ISSN: 0022-510X
EISSN: 1878-5883 
238 
Supplement 1 
S179-S179 
WOS:000235088001330 
Lead toxicity is a common popular problem. Many researches was. performed about this toxicity both invivo and invitro from 100 years. ago. Those studies showed that lead have toxic effects such as. behavioral disorders, decrease of IQ and decrease of learning. and memory. Also lead have neurotoxic effects such as decrease. of neuronal density in visual cortex of monkey, cell death in. hippocampus and decrease of acetylcolin in rat's hippocampus.. In this study we examin neurotoxic effects of lead on rat's radial nerve. because radial nerve is a mix nerve.. Materials and methods: 24 adult male rats was divided in six groups.. Groups I and II received lead acetate 4% and 2%, groups III and IV. received disttiled water and normal water for one month. After this. time, we killed rats and exposed radial nerve from behind of arm. Then. studied them with light and electron microscopy.. Results: In experimental groups we saw decrease of myelin sheath. diameter and decrease of nuclear density in schwann cell. Also we saw. many granules in mitochondrial matrix, active macrophage, edema. and disarrangement of myelin sheath layers.. Conclusion: We suggest that lead neurophaty is due to schwann cell. injury and this injury lead to decrease of myelin sheath.. Key words: nlyelin, radial nerve, lead (Pb). 
myelin, radial nerve, lead (Pb) 
• Inorganic Mercury Salts (2)
     Mercuric Chloride
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