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5928 
Technical Report 
Toxicology and carcinogenesis studies of isobutene (CAS no 115-11-7) in Fisher 344/N rats and B6C3F1 mice (inhalation studies) 
National Toxicology Program :: NTP 
1998 
National Toxicology Program 
Research Triangle Park, NC 
NTP TR 487 
GRA and I 
GRA and I 
240 
English 
Isobutene is produced during the fractionation of refinery gases or through the catalytic cracking of methyl-t-butyl ether. Isobutene is primarily used to produce diisobutylene, trimers, butyl rubber, and other polymers. In addition, it is used in the production of isooctane, high-octane aviation gasoline, methyl-t-butyl ether, and copolymer resins with butadiene and acrylonitrile. Isobutene was selected for evaluation because of the potential for human exposure due to its large production volume and the lack of adequate data on its carcinogenic potential. The toxicity and carcinogenicity of isobutene were determined in male and female F344/N rats and B6C3F1 mice exposed to isobutene (greater than 98% pure) by inhalation for 14 weeks or 2 years. The mutagenicity of isobutene was assessed in Salmonella typhimurium, and the frequency of micronuclei was determined in the peripheral blood of mice exposed by inhalation for 14 weeks. 
Toxicology; *Carcinogenesis; Lesions; Hyaline; Mice; Rats; Laboratory animals; Inhalation; Follicular; Carinoma; Thyroid; Isobutene; CAS No 115-11-7 
• Methanol (Non-Cancer)