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595084 
Journal Article 
Further improvements in the hepatocyte primary culture DNA repair test for carcinogens: Detection of carcinogenic biphenyl derivatives 
Williams, GM 
1978 
Yes 
Cancer Letters
ISSN: 0304-3835
EISSN: 1872-7980 
4 
2 
69-75 
English 
647653 
DNA repair in hepatocyte primary cultures was induced by simultaneous treatment with the carcinogen and [3H] thymidine for 18 h beginning immediately after attachment of cells. The unscheduled DNA synthesis elicited by carcinogens was determined by counting grains with an automatic grain counter. In 5 biphenyl derivatives, a correlation was found between carcinogenicity and the ability to induce DNA repair. Hence, the method offers promise as a means of screening chemical carcinogens. 
IRIS
• Biphenyl
     Considered
     Excluded References
     Cited References