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62341 
Journal Article 
Cytologic observations and cancer incidence following exposure to BCME 
Lemen, RA; Johnson, WM; Wagoner, JK; Archer, VE; Saccomanno, G 
1976 
Yes 
Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632 
271 
71-80 
English 
A hygiene survey was conducted among male employees of an anion-exchange resin production facility using bis(chloromethyl)ether (542881). Those employees with five or more years exposure to bis(chloromethyl)ether, BCME, had a statistically significant association with abnormal sputum cytology, or 34 percent as compared to 11 percent for uranium surface miners. A lung cancer incidence study was made of 136 male workers, 1955-1972; data are given on five cases of bronchogenic cancer. Other studies found similar incidences of lung cancer among BCME workers. Carcinogenicity of BCME was first demonstrated in mice and these results of occupational exposure studies indicate a need for prior animal testing of new chemicals. 
DCN-175812; NIOSH Author; Diagnostic techniques; Mortality data; Toxic substances; Alkylating agents; Chlorine compounds; Carcinogens; Carcinogenesis; Ethers; Screening 
IRIS
• Uranium
     Toxline
     Merged reference set
     Secondary Refinement
          Retained for manual screening
     Excluded:
          Not chemical specific
     Uranium Literature Search Update 3/2017
          Toxnet