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Citation
Tags
HERO ID
62912
Reference Type
Journal Article
Title
Dose-response and ultrastructural alterations in dioxane carcinogenesis. Influence of methylcholanthrene on acute toxicity
Author(s)
Argus, MF; Sohal, RS; Bryant, GM; Hoch-Ligeti, C; Arcos, JC
Year
1973
Is Peer Reviewed?
Yes
Journal
European Journal of Cancer
ISSN:
0959-8049
EISSN:
1879-0852
Book Title
European Journal of Cancer (1965)
Volume
9
Issue
4
Page Numbers
237-243
Language
English
PMID
4778367
DOI
10.1016/0014-2964(73)90088-1
Web of Science Id
WOS:A1973P526300001
URL
https://linkinghub.elsevier.com/retrieve/pii/0014296473900881
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Abstract
A dose-response study with dioxane revealed the hepatocarcinogenicity of this compound in male rats to be a function of the total oral dose administered. The progressive development of these tumors was studied histopathologically, and detailed electronmicroscopy was carried out on precancerous liver tissue and on hepatocellular carcinoma produced by dioxane. The LD50 dose of dioxane in male rats (5•60 g/kg body weight) is significantly decreased (5•18 g/kg) in animals pretreated with 3-methylcholanthrene. This suggests that a metabolite is involved in the toxicity and possibly carcinogenicity of dioxane, and that both may be potentiated by enzyme inducers. Because certain hydroperoxides are known to be carcinogenic, it was shown by micro-iodimetric titrations that the dioxane used does not contain a dioxane hydroperoxide and that no peroxide is formed under the conditions of administration.
Keywords
Animals; Carcinogens; Dioxins administration dosage toxicity; Dose-Response Relationship Drug; Enzyme Induction; Lethal Dose 50; Liver Neoplasms chemically induced pathology; Male; Methylcholanthrene pharmacology; Microscopy Electron; Neoplasms Experimental chemically induced pathology; Precancerous Conditions pathology; Rats
Tags
IRIS
•
1,4-Dioxane - with inhalation update
Final (2013)
External Review Draft (2011)
•
Dioxin (2012 Project Page for Final Report)
OPPT REs
•
OPPT_1,4-Dioxane_D. Exposure
Total – title/abstract screening
Supplemental Search
Consumer Use
•
OPPT_1,4-Dioxane_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
Animal hazard ID
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