US EPA

630082 

Journal Article 

Abstract 

Cyclotrimethylenetrinitramine (RDX)-induced ultrastructural changes in rat liver and kidney 

French, JE; Bradley, SL; Schneider, NR; Andersen, ME; Jenkins, L, Jr 

1976 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

37 

1 

122 

http://linkinghub.elsevier.com/retrieve/pii/S0041008X76800117
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is part of a larger document 3221920 Abstracts of papers for the Fifteenth Annual Meeting of the Society of Toxicology, Atlanta, Georgia

The toxicity, tissue distribution, and metabolism of cyclotrimethylenetrinitramine (RDX) have been studied. Yet, little information is available on morphological changes that might be attributed to it. Because RDX is a potential occupational or environmental contaminant, such information is necessary for the overall evaluation of RDX toxicity. The ultrastructure of rat liver and kidney was examined 24, 48 and 120 hr after dosing with 100 mg of RDX/kg po. Conventional transmission electron micrographs revealed hepatocytes with dilation of the rough endoplasmic reticulum, mit ochondrial swelling, and the presence of concentric membrane arrays 24 hr after RDX administration. Renal ultrastructural alteration was apparently restricted to the distal convoluted tubular cells. No consistent variation in ultrastructure was observed in glomerular cells, proximal convoluted tubular cells, and collecting tubular cells. The presence of erythrocytes in the nephron tubules indicated hematuria. By 48 hr, hepatocyte alteration was similar and of the same magnitude, except for the proliferation of smooth endoplasmic reticulum (SER). No consistent effects were observed on renal ultrastructure at 48 or 120 hr. At 120 hr, the characteristic hepatocyte alterations as described above persisted 

Fifteenth Annual Meeting of the Society of Toxicology 

Atlanta, GA 

March 14–18, 1976