Preliminary assessment of relative toxicity and mutagenicity potential of 1-nitroso-3,5-dinitro-1,3,5-triazacylcohexane (mononitroso-RDX) | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

630128

Reference Type

Technical Report

Title

Preliminary assessment of relative toxicity and mutagenicity potential of 1-nitroso-3,5-dinitro-1,3,5-triazacylcohexane (mononitroso-RDX)

Author(s)

Snodgrass, HL, Jr

Year

1984

Publisher

U.S. Army Environmental Hygiene Agency

Location

Aberdeen Proving Ground, MD

Report Number

ADA149351. USAEHA-75-51-0345-85

Number of Pages

Language

English

URL

http://www.dtic.mil/docs/citations/ADA149351
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Abstract

The munitions component, 1-nitroso-3,5-dinitro-1,3,5-triazacyclohexane (mononitroso-RDX), was assessed for its relative irritant, skin sensitization, and mutagenicity potential. It showed no potential for eye or skin irritation in rabbits following a single application. It did not prove to be a skin sensitizen to guinea pigs. Mononitroso-RDX showed positive mutagenic activity in three of four in vitro bioassays. This finding, in addition to its implicating chemical structure, would earmark the chemical as a suspect mutagen and/or carcinogen. Further testing is recommended to establish human risk. Interim protection and monitoring of operational personnel is also recommended until mutagenic/toxicological risks are resolved.

Keywords

rdx; toxicity; bioassay; carcinogens; guinea pigs; humans; in vitro analysis; irritation; molecular structure; mutagens; risk; sensitizing; skin(anatomy); test and evaluation

Edition

Final Report

NTIS Number

ADA149351