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6311528 
Technical Report 
EPA Report 
Guidelines for human exposure assessment 
U.S. Environmental Protection Agency :: U.S. EPA 
2019 
Yes 
Risk Assessment Forum 
Washington, DC 
EPA/100/B-19/001 
223 
English 
This Guidelines for Human Exposure Assessment provides an updated resource on assessing human exposure for exposure and risk assessors in the Agency, and for consultants, contractors or others who perform this type of work under Agency contract or sponsorship. EPA risk managers/decision makers need to be familiar with this document because it describes approaches, defines terminology and summarizes methods assessors use to support regulatory decisions. It also serves as a resource for others as to how EPA conducts exposure assessments. This document builds on and supersedes the 1992 Guidelines for Exposure Assessment (U.S. EPA 1992c), incorporates advances in the field since then, reflects current scientific practice across Agency programs and includes pertinent topics identified during public meetings and from a literature survey, including publications issued by the National Research Council of the National Academy of Sciences. It briefly describes the principles of exposure science and assessment, provides guidance on the various approaches for conducting an exposure assessment and presents references for more detailed information. It does not serve as a detailed instructional manual or supplant specific exposure guidance in use by Agency programs, nor does it endorse specific models or approaches that could have limited applicability or have become outdated. In addition, this Guidelines focuses on exposure assessment as currently practiced in EPA programs. This document does not include an exhaustive description of emerging topics, such as high-throughput exposure assessment or the implications of in vitro-based risk assessments on the field of exposure assessment. Aspects of these advances that have been published in the peer-reviewed literature, however, are included. Finally, this Guidelines provides links to exposure assessment tools and technical documents that address particular exposure assessment needs.

The focus of this Guidelines for Human Exposure Assessment is on human exposure to chemical agents in the non-occupational environment. The exposed populations (i.e., receptors) to which this document refers are adults and children or other vulnerable groups within the human population. 
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