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63192 
Journal Article 
Enzymatic dechlorination: Dechlorination of chloroethanes and propanes in vitro 
Van Dyke, RA; Wineman, CG 
1971 
Yes 
Biochemical Pharmacology
ISSN: 0006-2952
EISSN: 1873-2968 
Elsevier 
NIOSH/00156363 
20 
2 
463-470 
English 
4402457 
The enzymatic dechlorination of a series of chloroethanes and chloropropanes was investigated. It was found that these materials were dechlorinated enzymatically by an enzyme system located in hepatic microsomes. This system requires NADPH and oxygen, and is inducible by phenobarbital and benzpyrene, but not by methylcholanthrene. The pH optimum of this system was found to be 8.2. Evidence is presented that a factor is present in the 105,000 g supernatant which is necessary for optimum activity. This supernatant factor is not inducible. The dechlorination varied depending on the extent of chlorination of the ethane or propane.