US EPA

632868 

Book/Book Chapter 

ß-Chloroprene 

American Conference of Governmental Industrial Hygienists :: ACGIH 

1991 

American Conference of Governmental Industrial Hygienists 

Cincinnati, OH 

Documentation of the threshold limit values and biological exposure indices 

1 

301-304 

TLV Recommendation
There are marked disparities between the dose-response and reported effects from studies reported by U.S. and Russian investigators of the toxicity and hazards posed by exposure to chloroprene. The weight of both human and animal evidence for the carcinogenicity of chloroprene and for teratogenic and reproductive ef¬fects has to be considered as very limited or inadequate. The TLV Committee recommends aTLV-TWA of 10 ppm with a skin notation, based on the conclusion by von Oettingen and co-workers*4) that chloroprene probably can be absorbed through the skin in amounts sufficient to elicit acute effects. This TLV will protect exposed workers against the risk of systemic health effects. The TLV of 10 ppm for chloroprene Is equivalent to the TLV for 1,3-butadiene, a nonchlorinated analog of chloroprene. At this time, no STEL is recommended until additional toxicological data and industrial hygiene experience become available to provide a better base for quantifying on a toxicological basis what the STELshould be. The reader is encouraged to review the section on Excursion Limits in the "Introduction to the Chemical Substances" of the current TLV/BEI Booklet for guidance and control of excursions above the TLV-TWA, even when the 8-hour TWA is within the recommended limits. 

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