Health & Environmental Research Online (HERO)


Print Feedback Export to File
6333752 
Journal Article 
Distortion product otoacoustic emission sensitivity to different solvents in a population of industrial painters 
Sisto, R; Cerini, L; Sanjust, F; Carbonari, D; Gherardi, M; Gordiani, A; L'Episcopo, N; Paci, E; Pigini, D; Tranfo, G; Moleti, A 
2020 
Yes 
International Journal of Audiology
ISSN: 1499-2027
EISSN: 1708-8186 
TAYLOR & FRANCIS LTD 
ABINGDON 
443-454 
31910691 
WOS:000506120100001 
Objective: To evaluate the ototoxic effect of the exposure to different organic solvents and noise using distortion product otoacoustic emissions (DPOAEs). Design: The exposure to different solvents was evaluated by measuring, before and at the end of the work-shift, the urinary concentrations of solvent metabolites used as dose biomarkers. The urinary concentrations of DNA and RNA oxidation products were also measured as biomarkers of oxidative damage. The simultaneous exposure to noise was also evaluated. DPOAEs and pure tone audiometry (PTA) were used as outcome variables, and were correlated to the exposure variables using mixed effect linear regression models. Study sample: Seventeen industrial painters exposed to a solvent mixture in a naval industry. A sample size of 15 was estimated from previous studies as sufficient for discriminating small hearing level and DPOAE level differences (5 dB and 2 dB, respectively) at a 95% confidence level. Results: Statistically significant associations were found between the DPOAE level and the urinary dose biomarkers and the oxidative damage biomarkers. DPOAE level and the logarithm of the metabolite concentration showed a significant negative correlation. Conclusions: DPOAE are sensitive biomarkers of exposure to ototoxic substances and can be effectively used for the early detection of hearing dysfunction. 
Organic solvents; metabolites; otoacoustic emissions; noise 
• Ethylbenzene
     Litsearch Update April 2020
          WOS