Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
65020
Reference Type
Journal Article
Title
Embryo- and fetotoxicity of inhaled chloroform in rats
Author(s)
Schwetz, BA; Leong, BKJ; Gehring, PJ
Year
1974
Is Peer Reviewed?
Yes
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Volume
28
Issue
3
Page Numbers
442-451
Language
English
PMID
4851839
DOI
10.1016/0041-008X(74)90229-4
Web of Science Id
WOS:A1974T385200011
URL
http://
://WOS:A1974T385200011
Exit
Abstract
This study evaluated the effects of inhalation of subanesthetic concentrations of chloroform on rat embryonal and fetal development. Pregnant Sprague-Dawley rats were exposed to 30, 100 or 300 ppm chloroform for 7hr/day on days 6 through 15 of gestation. Exposure to chloroform caused an apparent decrease in the conception rate and a high incidence of fetal resorption (300 ppm), retarded fetal development (30, 100, 300 ppm), decreased fetal body measurements (30, 300 ppm) and a low incidence of acaudate fetuses with imperforate anus (100 ppm). Chloroform was not highly teratogenic but was highly embryotoxic. The results of this study disclosed no relationship between maternal toxicity and embryo or fetotoxicity as the result of exposure to chloroform by inhalation.
Tags
•
Chloroform 2018 Update
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Included Studies
FULL-TEXT REVIEW
Included
Animal
•
Chloroform Combined (current)
Chloroform (original)
Chloroform (2018 update)
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Included Studies
FULL-TEXT REVIEW
Included
Animal
•
Formaldehyde [archived]
Reproductive and Developmental Effects
Screened
Title/abstract
Not formaldehyde
Retroactive RIS import
2015
FA DevRepro 072115
Not FA-Exposure Criteria
Not FA-Exposure Criteria
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
Other sources and cited references
Literature Identification
Reproductive and Developmental Effects
Excluded
•
SR Automation
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity