Health & Environmental Research Online (HERO)


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651874 
Journal Article 
Review 
Photosensitivity in lupus erythematosus 
Kuhn, A; Beissert, S 
2005 
Yes 
Autoimmunity
ISSN: 0891-6934
EISSN: 1607-842X 
38 
7 
519-529 
English 
16373257 
Lupus erythematosus (LE) is an autoimmune disease which can be triggered by environmental factors such as solar irradiation. It has long been observed that especially ultraviolet (UV) exposure can induce and exacerbate skin lesions in patients with this disease. However, despite the frequency of photosensitivity in LE, the mechanisms by which UV irradiation activates autoimmune responses is only now becoming increasingly unfolded by advanced molecular and cellular biological investigations. Phototesting, according to a standardized protocol with UVA and UVB irradiation has proven to be a valid model to study photosensitivity in various subtypes of LE and to evaluate the underlying pathomechanisms of this disease. Detailed analysis of the molecular events that govern lesion formation in experimentally photoprovoced LE showed increased accumulation of apoptotic keratinocytes and impaired expression of the inducible nitric oxide synthase (iNOS). In the near future, gene expression profiling and proteomics will further increase our knowledge on the complexity of the "UV response" in LE. This review summarizes the current understanding of the clinical and molecular mechanisms that initiate photosensitivity in this disease. 
Humans; Lupus Erythematosus, Systemic/etiology/ immunology; Photosensitivity Disorders/complications/ immunology; Ultraviolet Rays/ adverse effects 
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