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65246 
Journal Article 
Behavioural response of rats during inhalation of trichloroethylene and carbon disulphide vapours 
Goldberg, ME; Johnson, HE; Pozzani, UC; Smyth, HF, Jr 
1964 
1 
Basic & Clinical Pharmacology & Toxicology
ISSN: 1742-7835
EISSN: 1742-7843 
NIOSH/00133326 
21 
36-44 
Behavioral changes produced by trichloroethylene (79016) (TCE) and carbon-disulfide (75150) (CS2) vapor inhalation were investigated in Carworth-Farm-E-rats. Discrete avoidance studies were performed. Rats were exposed to 125 parts per million (ppm) TCE or 195ppm CS2 for 4 hours per day, 5 days per week for several weeks. Trials were performed for 1 hour beginning after 2.75 hours of exposure. During the 8 day preexposure period, rats had an average of 4.4 shocks per hour during behavioral trials. During a 25 day exposure period for TCE, there was a significant increase in the number of shocks taken. There were variations in response patterns; some rats were affected early and some not affected until week 3; some developed tolerances, and some were continuously affected. There was a gradual return to normal avoidance responding during the recovery phase. For CS2 vapors, a significant increase in the number of shocks received was seen only during the last 8 days of a 15 day exposure period. The number of animals affected progressed from one to five throughout the course of repeated inhalation. Animals affected early remained affected during the entire exposure period. There was an average weight loss of 3.5 percent after CS2 exposure; no weight loss occurred after TCE exposure. The authors conclude that both TCE and CS2 cause significant alterations in behavior.