Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos | Health & Environmental Research Online (HERO)

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HERO ID

6575254

Reference Type

Journal Article

Title

Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos

Author(s)

Mensah, KB; Benneh, C; Forkuo, AD; Ansah, C; ,

Year

2019

Is Peer Reviewed?

Yes

Journal

Biochemistry Research International
ISSN: 2090-2247

Volume

2019

Language

English

PMID

31360547

DOI

10.1155/2019/7076986

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069753639&doi=10.1155%2f2019%2f7076986&partnerID=40&md5=a5f01bf91602418f67b4db78942b6d1d
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Abstract

Previous studies on cryptolepine, the antimalarial and cytotoxic alkaloid of Cryptolepis sanguinolenta, showed that it preferentially accumulates in rapidly proliferating cells and melanin-containing tissues. Subsequently, we demonstrated that cryptolepine was toxic to murine embryos in vivo but no signs of teratogenicity. in vivo developmental studies can be confounded by maternal effects. Here, we hypothesized that cryptolepine-induced embryo toxicity occurs at least partly through direct inhibition of embryogenesis rather than indirectly through the induction of maternal toxicity.