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6576140 
Journal Article 
Pulmonary function and functional capacity cut-off point to establish sarcopenia and dynapenia in patients with COPD 
Kamal Mansour, KM; Goulart, C; Soares de Carvalho-Junior, LC; Trimer, R; Borghi-Silva, A; Goncalves da Silva, AL; , 
2019 
Yes 
Jornal Brasileiro de Pneumologia
ISSN: 1806-3713 
SOC BRASILEIRA PNEUMOLOGIA TISIOLOGIA 
BRASILIA DF 
45 
6 
7 
English 
31644702 
WOS:000505050800011 
Objective: To establish a cut-off point for clinical and functional variables to determinate sarcopenia and dynapenia in COPD patients, and to analyze the impact of skeletal muscle dysfunction (SMD) on these variables. Methods: Cross-sectional study, screened COPD patients for sarcopenia or dynapenia through low muscle mass and hand grip strength (HGS). Clinical variables: pulmonary function, respiratory muscle strength and functional capacity (FC). The precision of the variables in determining points of predictive cut-off for sarcopenia or dynapenia were performed using the Receiver Operating Characteristic curve and two-way analysis of variance. Results: 20 COPD patients stratified for sarcopenia (n = 11) and dynapenia (n = 07). Sarcopenia group presented lower lean mass and lower maximal inspiratory pressure (MIP), decreased HGS, reduced FC (p<0.050). Dynapenia group presented reduced MIP, lower HGS and walked a shorter distance at Incremental shuttle walk test (ISWT) (p<0.050). We found cut-off points of forced expiratory volume in one second (FEV1), MIP and maximal expiratory pressure (MEP) and ISWT. It is possible to identify sarcopenia or dynapenia in these patients. We found the coexistence of the conditions (SMD effect) in COPD - reduction in the distance in the ISWT (p = 0.002) and %ISWT (p = 0.017). Conclusion: In moderate to very severe COPD patients the sarcopenia could be predicted by FEV1 (%predicted) < 52, MIP < 73 cmH(2)O, MEP < 126 cmH2O and distance traveled of < 295 m in ISWT. Whereas dynapenia could be predicted by FEV1 < 40%, MIP < 71 cmH2O, MEP < 110 cmH2O and distance of < 230 m traveled in ISWT. 
Sarcopenia; Chronic obstructive pulmonary disease; Musculoskeletal; muscle dysfunction; reference values; epidemiology; frailty; severity; mobility; overlap; Respiratory System 
IRIS
• Inorganic Mercury Salts (2)
     Mercuric Sulfide
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