The invention discloses an antibacterial repairing ointment for treating bedsore gangrene and a preparation method thereof, wherein the antibacterial repairing ointment comprises the following components: 2-5 parts of southern jasmine, 30-50 parts of cupressus sempervirens, 9-12 parts of bitter herb of Chinese pholidota, 15-20 parts of Siberian clinopodium herb, 22-27 parts of Sida acuta, 11-23 parts of areca peel, 8-14 parts of glossy privet fruit, 0.3-0.7 part of cassia twig, 11-20 parts of baical skullcap root, 10-20 parts of rhizoma paridis, 7-17 parts of stiff silkworm grass, 7-16 parts of liquorice, 4-13 parts of sculellaria barbata, 4-10 parts of calomel, 40-80 parts of myrrh, 60-90 parts of safflower, 90-120 parts of pseudo-ginseng, 30-70 parts of grassleaf sweelflag rhizome, 9-15 parts of musk and 0.5-3 parts of ozone oil. The medicines of the invention can clear away heat and toxic material, sterilize and decontaminate, promote granulation and remove necrosis, effectively treat bedsore gangrene, have no irritation and are convenient to treat. The ozone oil of the invention has the function of killing various pathogenic microorganisms. The byproducts generated by ozone killing and killing pathogenic microorganisms are oxygen and gaseous water molecules which can be absorbed by cell tissues, accelerate blood circulation and promote the healing of the skin of an affected part.